Copper that cancer with lysosomal love! (Editorial)
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Sahni, Sumit
Richardson, Des R
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Abstract
There is now extensive evidence that chelation of copper and/or iron can inhibit tumour growth in cell culture, animal models and human clinical trials. These effects are due to the essential role these metal ions play in a variety of biological processes, including DNA synthesis. As such, there is growing interest in the development of new agents that surpass the anti-tumor activity of traditional metal-binding drugs such as desferrioxamine (DFO)
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Aging-US
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8
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2
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© The Author(s) 2016. This is an Open Access article distributed under the terms of the Creative Commons Attribution 3.0 Unported (CC BY 3.0) License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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Biochemistry and cell biology
Zoology
Oncology and carcinogenesis
Science & Technology
Life Sciences & Biomedicine
Geriatrics & Gerontology
Dp44mT
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Kovacevic, Z; Sahni, S; Richardson, DR, Copper that cancer with lysosomal love! (Editorial), Aging-US, 2016, 8 (2), pp. 210-211