This critical essay endeavors to make visible the basic assumptions underlying colonial and neo-colonial systems. The main principle posits that the global system’s dominant ideologies are maintained by ubiquitous discourses imposed as epistemological underpinnings of so-called modernity. This reflection concludes that it is necessary to recognize the epistemological status of indigenous resistance histories as new referents for the theorization and transformation of dominant and opaque discourses of the Modern World System.