Linkage mapping of CVD risk traits in the isolated Norfolk Island population

No Thumbnail Available
File version
Author(s)
Bellis, Claire
Cox, Hannah
Dyer, T.
Charlesworth, J.
Begley, Kimberly
Quinlan, Sharon
Lea, Rodney
Heath, S.
Blangero, J.
Griffiths, Lyn
Primary Supervisor
Other Supervisors
Editor(s)

Dr. David N Cooper, Dr. Thomas J Hudson

Date
2008
Size
File type(s)
Location
License
Abstract

To understand the underlying genetic architecture of cardiovascular disease (CVD) risk traits, we undertook a genome-wide linkage scan to identify CVD quantitative trait loci (QTLs) in 377 individuals from the Norfolk Island population. The central aim of this research focused on the utilization of a genetically and geographically isolated population of individuals from Norfolk Island for the purposes of variance component linkage analysis to identify QTLs involved in CVD risk traits. Substantial evidence supports the involvement of traits such as systolic and diastolic blood pressures, high-density lipoprotein-cholesterol, low-density lipoprotein-cholesterol, body mass index and triglycerides as important risk factors for CVD pathogenesis. In addition to the environmental inXuences of poor diet, reduced physical activity, increasing age, cigarette smoking and alcohol consumption, many studies have illustrated a strong involvement of genetic components in the CVD phenotype through family and twin studies. We undertook a genome scan using 400 markers spaced approximately 10 cM in 600 individuals from Norfolk Island. Genotype data was analyzed using the variance components methods of SOLAR. Our results gave a peak LOD score of 2.01 localizing to chromosome 1p36 for systolic blood pressure and replicated previously implicated loci for other CVD relevant QTLs.

Journal Title

Human Genetics

Conference Title
Book Title
Edition
Volume

124

Issue
Thesis Type
Degree Program
School
Publisher link
Patent number
Funder(s)
Grant identifier(s)
Rights Statement
Rights Statement
Item Access Status
Note
Access the data
Related item(s)
Subject

Genetics

Complementary and Alternative Medicine

Paediatrics and Reproductive Medicine

Persistent link to this record
Citation
Collections