Ficus racemosa L. Leaf Extracts Lack Antibacterial activity and are Toxic in vitro

Loading...
Thumbnail Image
File version

Version of Record (VoR)

Author(s)
Mpala, Lindiwe
Chikowe, Getmore
Cock, Ian Edwin
Primary Supervisor
Other Supervisors
Editor(s)
Date
2019
Size
File type(s)
Location
Abstract

Introduction: Closely related plant species often share similar secondary metabolites and bioactivities and are therefore good targets for bioactivity testing when one or more species within a genus are known to possess therapeutic properties. The genus Ficus has a long history of medicinal usage in many areas of the world. Many species are known to have therapeutic properties, several species of which have well established antibacterial bioactivities. Methods: The ability of F. racemosa leaf extracts to inhibit the growth of a panel of bacterial pathogens was investigated by disc diffusion assay. Toxicity was examined using the Artemia franciscana nauplii bioassay. Results: F. racemosa methanolic and aqueous extracts were completely ineffective at inhibiting the growth of gram-positive and gram-negative panels of bacteria. The extracts were nontoxic or of low toxicity following 24 h exposure. Conclusion: Despite the close taxonomic relationship with several bioactive Ficus spp. and its therapeutic uses in traditional medicine, F. racemosa leaf extracts were completely ineffective bacterial growth inhibitors. However, these extracts may have other therapeutic properties and testing against protozoa, fungi, virus and tumour cells is required.

Journal Title

Pharmacognosy Communications

Conference Title
Book Title
Edition
Volume

10

Issue

1

Thesis Type
Degree Program
School
Publisher link
Patent number
Funder(s)
Grant identifier(s)
Rights Statement
Rights Statement

© The Author(s) 2020. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International (CC BY-NC-ND 4.0) License (http://creativecommons.org/licenses/by-nc-nd/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, providing that the work is properly cited.

Item Access Status
Note
Access the data
Related item(s)
Subject

Plant Biology

Pharmacology and Pharmaceutical Sciences

Persistent link to this record
Citation

Mpala, L; Chikowe, G; Cock, IE, Ficus racemosa L. Leaf Extracts Lack Antibacterial activity and are Toxic in vitro, Pharmacognosy Communications, 2019, 10 (1), pp. 52-56

Collections