This study examines the sensitivity of the global uranium sector to equity markets, financial indicators, and geopolitical risks since 2010, with a particular focus on the Russia–Ukraine war which has significantly disrupted uranium supply chains, pricing, and geopolitical alliances, amplifying the sector's exposure to macroeconomic and geopolitical forces. The findings highlight the strong influence of global equity and oil markets, intensified in the last three years, while economic policy uncertainty remains relevant at high return quantiles. The impact of geopolitical risks is identified as a significant driver since 2022, at both the right and left tail of the uranium sector return distribution.