Partnerships with local public sector agencies, enterprises and tertiary institutions offer a means to inform young people about post-school pathways into working life and occupations that schools alone cannot achieve. Informing about those pathways is an important, yet, complex educational goal for schooling. This is because much of schooling effort privileges and is directed towards higher education entry. Often advice provided to young people through schools is by teachers and administrators who are, understandably, unacquainted with the range of post-school pathways other than higher education. School guidance officers report being ill-equipped and unable to provide students personalised advice. Consequently, sources of advice and experiences beyond the school are now being utilised, particularly through the growing role of partnerships. These partnerships take diverse forms and comprise different kinds of institutional alignments and are increasingly being viewed as essential bases for supporting effective and informed post-school transitions. This article presents and discusses a review of literature and a recent investigation to advance principles and practices of how such partnerships can be best initiated, enacted, and sustained over time and they can meet the goals of informing and guiding young people’s pathways, including options other than progression to higher education.