Horizontal transfer of mitochondria between mammalian cells: Beyond co-culture approaches

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Berridge, Michael V
McConnell, Melanie J
Grasso, Carole
Bajzikova, Martina
Kovarova, Jaromira
Neuzil, Jiri
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2016
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Current dogma holds that genes are the property of individual mammalian cells and partition between daughter cells during cell division. However, and rather unexpectedly, recent research has demonstrated horizontal cell-to-cell transfer of mitochondria and mitochondrial DNA in several mammalian cell culture systems. Furthermore, unequivocal evidence that mitochondrial DNA transfer occurs in vivo has now been published. While these studies show horizontal transfer of mitochondrial DNA in pathological settings, it is also possible that intercellular mitochondrial transfer is a fundamental physiological process with a role in development and tissue homeostasis.

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Current Opinion in Genetics & Development

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38

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Genetics

Genetics not elsewhere classified

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