Do polymorphisms in the familial Parkinsonism genes contribute to risk for sporadic Parkinson's disease?

No Thumbnail Available
File version
Author(s)
Sutherland, Greg T
Halliday, Glenda M
Silburn, Peter A
Mastaglia, Frank L
Rowe, Dominic B
Boyle, Richard S
O'Sullivan, John D
Ly, Tina
Wilton, Steve D
Mellick, George D
Griffith University Author(s)
Primary Supervisor
Other Supervisors
Editor(s)

Guenther Deuschl,

Date
2009
Size
File type(s)
Location
License
Abstract

Recent whole genome association studies provided little evidence that polymorphisms at the familial Parkinsonism loci influence the risk for Parkinson's disease (PD). However, these studies are not designed to detect the types of subtle effects that common variants may impose. Here, we use an alternative targeted candidate gene approach to examine common variation in 11 genes related to familial Parkinsonism. PD cases (n = 331) and unaffected control subjects (n = 296) were recruited from three specialist movement disorder clinics in Brisbane, Australia and the Australian Electoral Roll. Common genetic variables (76 SNPs and 1 STR) were assessed in all subjects and haplotype, genotype, and allele associations explored. Modest associations (uncorrected P < 0.05) were observed for common variants around SNCA, UCHL1, MAPT, and LRRK2 although none were of sufficient magnitude to survive strict statistical corrections for multiple comparisons. No associations were seen for PRKN, PINK1, GBA, ATP13A2, HTRA2, NR4A2, and DJ1. Our findings suggest that common genetic variables of selected PD-related loci contribute modestly to PD risk in Australians.

Journal Title

Movement Disorders

Conference Title
Book Title
Edition
Volume

24

Issue

6

Thesis Type
Degree Program
School
Publisher link
Patent number
Funder(s)
Grant identifier(s)
Rights Statement
Rights Statement

© 2009 Movement Disorders Society. Published by John Wiley & Sons, Ltd. Self-archiving of the author-manuscript version is not yet supported by the Movement Disorders Society. Please refer to the journal link for access to the definitive, published version or contact the authors for more information.

Item Access Status
Note
Access the data
Related item(s)
Subject

Clinical sciences

Sports science and exercise

Neurosciences

Neurology and neuromuscular diseases

Persistent link to this record
Citation
Collections