Atypical finding of meningothelial-like inclusions in cervical lymph nodes

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Donkin, Rebecca
Dettrick, Andrew
Wyche, Penelope
Grigg, Sarah
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2018
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Sir, Incidental findings of benign spindle-shaped cells with oval to indented spindle nuclei inclusions have been described predominantly in lung cancer cases and given the name minute pulmonary meningothelial-like nodules or MPMN.1, 2, 3 It was proposed by Gaffey et al. in 19881 that the morphological characteristics of a meningothelial-like nodule closely resemble meningothelial cells. This relationship has been supported by immunohistochemical (IHC) analysis which reveals the strong reactivity of MPMN to epithelial membrane antigen (EMA) and the filament protein vimentin. In contrast, other papers have reported ‘meningothelial-like whorls’ from tissue outside of the lung,2, 3, 4 describing positive staining for myosin, alpha smooth muscle actin (α-SMA) and negative for EMA, suggesting muscle origin. Due to the inconsistent IHC results, the origin of these benign inclusions is unclear. It is yet to be determined if anatomical location of the inclusion reflects the IHC profile. Herein, we report a unique case of benign meningothelial inclusions in cervical lymph nodes, which has not been reported previously to the authors' knowledge.

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Pathology

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50

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7

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Clinical sciences

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Life Sciences & Biomedicine

Pathology

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Donkin, R; Dettrick, A; Wyche, P; Grigg, S, Atypical finding of meningothelial-like inclusions in cervical lymph nodes, Pathology, 2018, 50 (7), pp. 785-787

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