This research employs creative practice to develop a screenwriting framework for writing antiheroines for the erotic thriller film genre. It comprises the creative artefact, the screenplay titled Perfect Wife, and this exegesis, which underpins and contextualises the screenplay and incrementally develops the “Genre Screenwriting Practice Framework”, thus contributing to the academic field of script development and screenwriting as creative practice. The research findings aim to assist screenwriters in the development of antiheroine protagonists for the erotic thriller genre as well as the genre itself. Drawing from transdisciplinary fields including script development, screen studies, and film genre theory, “Writing Antiheroines for the Erotic thriller” follows my creative journey in the development of the female version of the erotic thriller antihero, a figure who arguably is yet to be seen in mainstream erotic thriller feature films.