Post-traumatic stress disorder affects fucose-α(1–2)-glycans in the human brain: preliminary findings of neuro deregulation using in vivo two-dimensional neuro MR spectroscopy
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Tosh, Nathan
Urquhart, Aaron
Trickey, Katie
Tremewan, Rosanna
Galloway, Graham
Rich, Lisa
Lea, Rodney
Malycha, Peter
Mountford, Carolyn
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Abstract
Post-traumatic stress disorder (PTSD) is triggered by experiencing terrifying event(s) for which there is currently no objective test for a definitive diagnosis. We report a pilot study where two-dimensional (2D) neuro magnetic resonance spectroscopy (MRS), collected at 3 T in a clinical scanner with a 64-channel head coil, identifies neuro deregulation in the PTSD cohort. The control subjects (n = 10) were compared with PTSD participants with minimal co-morbidities (n = 10). The 2D MRS identified statistically significant increases in the total spectral region containing both free substrate fucose and fucosylated glycans of 31% (P = 0.0013), two of multiple fucosylated glycans (Fuc IV and VI) were elevated by 48% (P = 0.002), and 41% (P = 0.02), respectively, imidazole was increased by 12% (P = 0.002), and lipid saturation was increased by 12.5% (P = 0.009). This is the first evidence of fucosylated glycans, reported in animals to be involved in learning and memory, to be affected in humans with PTSD.
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Translational Psychiatry
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9
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© The Author(s) 2019. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
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Clinical sciences
Psychology
Public health
Science & Technology
Life Sciences & Biomedicine
Psychiatry
POSTERIOR CINGULATE CORTEX
PROTON-MAGNETIC-RESONANCE
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Quadrelli, S; Tosh, N; Urquhart, A; Trickey, K; Tremewan, R; Galloway, G; Rich, L; Lea, R; Malycha, P; Mountford, C, Post-traumatic stress disorder affects fucose-α(1–2)-glycans in the human brain: preliminary findings of neuro deregulation using in vivo two-dimensional neuro MR spectroscopy, Translational Psychiatry, 2019, 9, pp. 27