Evaluation of the 2-Aminomethylphenol JPC-2997 in Aotus Monkeys Infected with Plasmodium falciparum (Letter)
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Harris, Ivor
van Breda, Karin
De, Sai Lata
Stanisic, Danielle I
Good, Michael F
Jacobus, David P
Edstein, Michael D
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Abstract
Previously, we reported JPC-2997 [4-(tert-Butyl)-2-((tert-butylamino)methyl)-6-(6-(trifluoromethyl)pyridin-3-yl)-phenol] to possess high in vitro antimalarial activity against Plasmodium falciparum lines, low cytotoxicity in mammalian cell lines, a long blood elimination half-life in Aotus monkeys (10.8 days), and potent in vivo efficacy against animal malaria models (1). Herein, as planned by Birrell et al., we report on the in vivo efficacy of JPC-2997 against the chloroquine- and quinine-resistant P. falciparum FVO strain in Aotus monkeys.
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Antimicrobial Agents and Chemotherapy
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60
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3
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Microbiology
Medical microbiology
Pharmacology and pharmaceutical sciences
Science & Technology
Life Sciences & Biomedicine
Microbiology
Pharmacology & Pharmacy
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McCallum, F; Harris, I; van Breda, K; De, SL; Stanisic, DI; Good, MF; Jacobus, DP; Edstein, MD, Evaluation of the 2-Aminomethylphenol JPC-2997 in Aotus Monkeys Infected with Plasmodium falciparum, Antimicrobial Agents and Chemotherapy, 2016, 60 (3), pp. 1948-1949