Evaluation of the 2-Aminomethylphenol JPC-2997 in Aotus Monkeys Infected with Plasmodium falciparum (Letter)

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McCallum, Fiona
Harris, Ivor
van Breda, Karin
De, Sai Lata
Stanisic, Danielle I
Good, Michael F
Jacobus, David P
Edstein, Michael D
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2016
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Abstract

Previously, we reported JPC-2997 [4-(tert-Butyl)-2-((tert-butylamino)methyl)-6-(6-(trifluoromethyl)pyridin-3-yl)-phenol] to possess high in vitro antimalarial activity against Plasmodium falciparum lines, low cytotoxicity in mammalian cell lines, a long blood elimination half-life in Aotus monkeys (10.8 days), and potent in vivo efficacy against animal malaria models (1). Herein, as planned by Birrell et al., we report on the in vivo efficacy of JPC-2997 against the chloroquine- and quinine-resistant P. falciparum FVO strain in Aotus monkeys.

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Antimicrobial Agents and Chemotherapy

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60

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3

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Microbiology

Medical microbiology

Pharmacology and pharmaceutical sciences

Science & Technology

Life Sciences & Biomedicine

Microbiology

Pharmacology & Pharmacy

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McCallum, F; Harris, I; van Breda, K; De, SL; Stanisic, DI; Good, MF; Jacobus, DP; Edstein, MD, Evaluation of the 2-Aminomethylphenol JPC-2997 in Aotus Monkeys Infected with Plasmodium falciparum, Antimicrobial Agents and Chemotherapy, 2016, 60 (3), pp. 1948-1949

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