A Randomized Controlled Trial of Robotic Versus Open Radical Prostatectomy: Early Outcomes
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Yaxley, John W
Coughlin, Geoffrey D
Chambers, Suzanne K
Occhipinti, Stefano
Samaratunga, Hema
Zaidlewicz, Leah
Dunglison, Nigel
Carter, Rob
Williams, Scott
Payton, Diane J
Perry-Keene, Joanna
Lavin, Martin F
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Brisbane, Australia
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Abstract
Background: The lack of trial data comparing robot-assisted laparoscopic prostatectomy (RALP) and open radical retropubic prostatectomy (RRP) is a critical knowledge gap in uro-oncology. A randomized controlled trial (RCT) compared these two approaches on functional and oncological outcomes.
Method: A phase III RCT compared RRP with RALP: 326 men with localized prostate cancer were randomized (RRP n = 163 and RALP n = 163), 18 withdrew and 151 and 157, respectively, proceeded to surgery. Primary outcomes were urinary and sexual function. Secondary outcomes included bowel function and health-related quality of life, pain, time to return to usual activities up to 12 weeks postsurgery and positive surgical margins.
Findings: The results at 6 and 12 weeks postsurgery and time to return to work will be presented.
Registration: The trial was registered with the Australian New Zealand Clinical Trials Registry, number ACTRN12611000661976.
Funding: Cancer Council Queensland.
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Asia-Pacific Journal of Clinical Oncology
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12
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S3
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Oncology and carcinogenesis
Science & Technology
Life Sciences & Biomedicine
Oncology
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Gardiner, RF; Yaxley, JW; Coughlin, GD; Chambers, SK; Occhipinti, S; Samaratunga, H; Zaidlewicz, L; Dunglison, N; Carter, R; Williams, S; Payton, DJ; Perry-Keene, J; Lavin, MF, A Randomized Controlled Trial of Robotic Versus Open Radical Prostatectomy: Early Outcomes, Asia-Pacific Journal of Clinical Oncology, 2016, 12 (S3), pp. 29-29