Replication of the Frank-Starling response in a mock circulation loop

Loading...
Thumbnail Image
File version

Accepted Manuscript (AM)

Author(s)
Gregory, Shaun D
Stevens, Michael
Timms, Daniel
Pearcy, Mark
Griffith University Author(s)
Primary Supervisor
Other Supervisors
Editor(s)

Jorge E. Monzon and James L. Patton

Date
2011
Size
File type(s)
Location

Boston, MA

License
Abstract

Mock circulation loops (MCLs) are used to evaluate cardiovascular devices prior to in-vivo trials; however they lack the vital autoregulatory responses that occur in humans. This study aimed to develop and implement a left and right ventricular Frank-Starling response in a MCL. A proportional controller based on ventricular end diastolic volume was used to control the driving pressure of the MCL's pneumatically operated ventricles. Ventricular pressure-volume loops and end systolic pressure-volume relationships were produced for a variety of healthy and pathological conditions and compared with human data to validate the simulated Frank-Starling response. The non-linear Frank-Starling response produced in this study successfully altered left and right ventricular contractility with changing preload and was validated with previously reported data. This improvement to an already detailed MCL has resulted in a test rig capable of further refining cardiovascular devices and reducing the number of in-vivo trials.

Journal Title
Conference Title

2011 ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY (EMBC)

Book Title
Edition

1st

Volume

2011

Issue
Thesis Type
Degree Program
School
Publisher link
Patent number
Funder(s)
Grant identifier(s)
Rights Statement
Rights Statement

© 2011 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works.

Item Access Status
Note
Access the data
Related item(s)
Subject

Biomedical engineering not elsewhere classified

Persistent link to this record
Citation