The role of exercise in the management of adverse effects of androgen deprivation therapy for prostate cancer: a rapid review

Loading...
Thumbnail Image
File version

Accepted Manuscript (AM)

Author(s)
Edmunds, Kim
Tuffaha, Haitham
Scuffham, Paul
Galvao, Daniel A
Newton, Robert U
Griffith University Author(s)
Primary Supervisor
Other Supervisors
Editor(s)
Date
2020
Size
File type(s)
Location
License
Abstract

Purpose: Prostate cancer (PCa) is the most commonly diagnosed cancer in Australia, accounting for one quarter of all new cancer diagnoses for males. Androgen deprivation therapy (ADT) is the standard first-line therapy for metastatic PCa but is also used across much of the spectrum of disease. Unfortunately, debilitating adverse effects are a significant and largely unavoidable feature of ADT. A recent systematic review of adverse effects of ADT identified 19 sub-groups classified according to the Common Terminology Criteria for Adverse Events (CTCAE) Version 5.0. The potential for multiple simultaneous adverse effects, their associated management and the impact of adverse effects on cancer outcomes and quality of life are important considerations in the treatment and supportive care of men with PCa. Exercise is increasingly being recognized as an efficacious strategy in managing these adverse effects. Methods: A rapid review was undertaken to examine the role of exercise in the management of the most commonly reported ADT adverse effects classified according to the CTCAE sub-groups. A systematic search was conducted in Medline, PsycINFO, Google Scholar and Google for the years 2010 to September 2019 to identify the benefits of exercise in managing the adverse effects of ADT for PCa. Results: There is strong evidence for exercise as medicine in addressing several of the adverse effects of PCa such as loss of muscle mass and strength, fatigue and declining physical function. Moderate level evidence for PCa exists for exercise-induced improvements in depression and anxiety, bone loss, and sexual dysfunction. While evidence of the effectiveness of exercise is lacking for many adverse effects of ADT for PCa, evidence in the cancer population as a whole or other clinical populations is strong, and many clinical guidelines recommend exercise as a fundamental part of their clinical management. With the exception of gynaecomastia and breast pain, there is increasing evidence (PCa, cancer or other clinical populations) to suggest that exercise has the potential to reduce and even prevent many of the adverse effects of ADT, thus improving survivorship outcomes for men with PCa. Conclusion: Exercise has the potential to reduce and even prevent many of the adverse effects of ADT, thus improving survivorship outcomes for men with PCa. The use of exercise for PCa management has the potential to translate into health and economic benefits in improved quality of life and fewer complications, resulting in savings to the health care system, enhanced productivity and reduced patient and carer burden. Exercise thus has the potential to improve quality of life for this population as well as generate significant cost savings.

Journal Title

Supportive Care in Cancer

Conference Title
Book Title
Edition
Volume
Issue
Thesis Type
Degree Program
School
Publisher link
Patent number
Funder(s)
Grant identifier(s)
Rights Statement
Rights Statement

© 2020 Springer Berlin/Heidelberg. This is an electronic version of an article published in Supportive Care in Cancer, 2020. Supportive Care in Cancer is available online at: http://link.springer.com/ with the open URL of your article.

Item Access Status
Note
Access the data
Related item(s)
Subject

Biomedical and clinical sciences

Clinical sciences

Psychology

Adverse effects

Androgen deprivation therapy

Exercise medicine

Management

Prostate cancer

Persistent link to this record
Citation

Edmunds, K; Tuffaha, H; Scuffham, P; Galvão, DA; Newton, RU, The role of exercise in the management of adverse effects of androgen deprivation therapy for prostate cancer: a rapid review., Supportive Care in Cancer, 2020

Collections