Stability of vancomycin hydrochloride employed in antimicrobial seal solutions of central intravenous catheters
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de Carvalho Onofre, Priscilla Sete
Affonso Fonseca, Fernando Luiz
Pires Rosa, Paulo Cesar
Goncalves Pedreira, Mavilde da Luz
Sorgini Peterlini, Maria Angelica
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Objective: to verify the stability of vancomycin hydrochloride in antimicrobial seal solutions with and without association of heparin sodium according to temperature and association time. Method: an experimental study designed for the analysis of hydrogenionic potential and concentration by means of high-efficiency liquid chromatography of vancomycin hydrochloride (n=06) and vancomycin hydrochloride and heparin sodium (n=06). The solutions studied were submitted to absence of light, as well as to 22°C and 37°C. Analyses in triplicate (n=192) were performed at the initial moment (T0) and three (T3), eight (T8) and 24 hours (T24) after preparation. The data were submitted to analysis of variance (p≤0.05). Results: concentration of the antimicrobial at 22°C presented a reduction (T0-T8) and a subsequent increase (T24); hydrogenionic potential decreased significantly over time. At 37°C, the concentration increased up to T3 and decreased at T24, with a reduction of hydrogenionic potential up to 24 hours. Concentration of the vancomycin hydrochloride and heparin sodium solutions varied with a reduction at 22°C, accompanied by increased hydrogenionic potential. Precipitate formation was observed by visual inspection of the vancomycin hydrochloride-heparin sodium association (T3). Conclusion: pharmacological stability of vancomycin hydrochloride (5 mg/mL) and physical incompatibility with heparin sodium (100 IU/mL) were evidenced after three hours of association in the antimicrobial seal solutions studied.
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Revista Latino-Americana de Enfermagem
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30
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© 2022 Revista Latino-Americana de Enfermagem. This is an Open Access article distributed under the terms of the Creative Commons (CC BY). This license lets others distribute, remix, tweak, and build upon your work, even commercially, as long as they credit you for the original creation. This is the most accommodating of licenses offered. Recommended for maximum dissemination and use of licensed materials.
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Subject
Nursing
Catheter-Related Infections
COMPATIBILITY
Drug Stability
Heparin
Infusions
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Barros, DP; de Carvalho Onofre, PS; Affonso Fonseca, FL; Pires Rosa, PC; Goncalves Pedreira, MDL; Sorgini Peterlini, MA, Stability of vancomycin hydrochloride employed in antimicrobial seal solutions of central intravenous catheters, Revista Latino-Americana de Enfermagem, 2022, 30, pp. e3621