The macrophage-inducible C-type lectin, mincle, is an essential component of the innate immune response to Candida albicans
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Author(s)
Salvage-Jones, Judith
Li, Xin
Hitchens, Kelly
Butcher, Suzanne
Z. Murray, Rachel
Beckhouse, Anthony
Lo, Yu-Lan Sandra
Manzanero Alonso, Silvia
Cobbold, Christian
Schroder, Kate
Ma, Bo
Orr, Sally
Stewart, Lauren
Lebus, Daniel
Sobieszczuk, Peter
A. Hume, David
Stow, Jennifer
Blanchard, Helen
Ashman, Robert
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Jeremy M. Boss
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Abstract
The recognition of carbohydrate moieties by cells of the innate immune system is emerging as an essential element in antifungal immunity, but despite the number and diversity of lectins expressed by innate immune cells, few carbohydrate receptors have been characterized. Mincle, a C-type lectin, is expressed predominantly on macrophages, and is here shown to play a role in macrophage responses to the yeast Candida albicans. After exposure to the yeast in vitro, Mincle localized to the phagocytic cup, but it was not essential for phagocytosis. In the absence of Mincle, production of TNF-{alpha} by macrophages was reduced, both in vivo and in vitro. In addition, mice lacking Mincle showed a significantly increased susceptibility to systemic candidiasis. Thus, Mincle plays a novel and nonredundant role in the induction of inflammatory signaling in response to C. albicans infection.
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Journal of Immunology
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180
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11
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Immunology