This chapter discusses the way that many of the contributions to this edited volume on the boundary between learning and work infer, emphasise or directly state that interdependencies between societal and personal factors shape how individuals work and learn, but also of the relations between working and learning. Hence, when taken as a central explanatory concept, interdependencies seem ubiquitous to much of the discussion, theorisations and accounts of work and learning and the boundaries between them. Consequently, it is necessary to elaborate what constitutes interdependencies and in what ways they constitute a comprehensive explanatory account of processes of working and learning. This is achieved through a consideration of the central role of interdependencies in both work and learning, and the relations between them, followed by a set of three premises upon which such an explanation is founded. Following this, an elaboration of these interdependencies in terms of the suggestion and projection of the social world and also the personal process of construing and constructing what is experienced in responding to it in personally agentic ways is then advanced. Central here is the active and engaged participation by individuals in both work and learning, as a key mechanism of that interdependence. Throughout, reference to the contributions to this volume are included and then, finally and in summary in summary, how interdependence is central to these contributions is then advanced in conclusion.