The emerging role of long non-coding RNAs in HIV infection

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Lazar, Daniel C
Morris, Kevin V
Saayman, Sheena M
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2016
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Abstract

The discovery of long non-coding RNAs (lncRNAs) and the elucidation of the mechanisms by which they affect different disease states are providing researchers with a better understanding of a wide array of disease pathways. Moreover, lncRNAs are presenting themselves as both unique diagnostic biomarkers as well as novel targets against which to develop new therapeutics. Here we will explore the intricate network of non-coding RNAs associated with infection by the human immunodeficiency virus (HIV). Non-coding RNAs derived from both the human host as well as those from HIV itself are emerging as important regulatory elements. We discuss here the various mechanisms through which both small and long non-coding RNAs impact viral replication, pathogenesis and disease progression. Given the lack of an effective vaccine or cure for HIV and the scale of the current pandemic, a deeper understanding of the complex interplay between non-coding RNAs and HIV will support the development of innovative strategies for the treatment of HIV/acquired immunodeficiency disease (AIDS).

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Virus Research

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212

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© 2015 Elsevier B.V. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/

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Biological sciences

Agricultural, veterinary and food sciences

Biomedical and clinical sciences

Science & Technology

Life Sciences & Biomedicine

Virology

HIV

IncRNA

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Lazar, DC; Morris, KV; Saayman, SM, The emerging role of long non-coding RNAs in HIV infection, Virus Research, 2016, 212, pp. 114-126

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