Iotrochamides A and B, antitrypanosomal compounds from the Australian marine sponge Iotrochota sp.
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Davis, Rohan A
Sykes, Melissa L
Avery, Vicky M
Quinn, Ronald J
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Abstract
Bioassay-guided isolation of the CH2Cl2/MeOH extract from the Australian sponge Iotrochota sp. resulted in the purification of two new N-cinnamoyl-amino acids, iotrochamides A (1) and B (2). The chemical structures of 1 and 2 were determined by 1D/2D NMR and MS data analyses. Compounds 1 and 2 were shown to inhibit Trypanosoma brucei brucei with IC50 values of 3.4 and 4.7 卬 respectively.
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Bioorganic and Medicinal Chemistry Letters
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22
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14
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© 2012 Elsevier. This is the author-manuscript version of this paper. Reproduced in accordance with the copyright policy of the publisher. Please refer to the journal's website for access to the definitive, published version.
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Medicinal and biomolecular chemistry
Biologically active molecules
Organic chemistry
Pharmacology and pharmaceutical sciences