Epstein–Barr virus-associated lymphomas decoded
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Chowdhury, R
Tobin, JWD
Swain, F
Keane, C
Boyle, S
Khanna, R
Gandhi, MK
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Abstract
Epstein–Barr virus (EBV)-associated lymphomas cover a range of histological B- and T-cell non-Hodgkin and Hodgkin lymphoma subtypes. The role of EBV on B-cell malignant pathogenesis and its impact on the tumour microenvironment are intriguing but incompletely understood. Both the International Consensus Classification (ICC) and 5th Edition of the World Health Organization (WHO-HAEM5) proposals give prominence to the distinct clinical, prognostic, genetic and tumour microenvironmental features of EBV in lymphoproliferative disorders. There have been major advances in our biological understanding, in how to harness features of EBV and its host immune response for targeted therapy, and in using EBV as a method to monitor disease response. In this article, we showcase the latest developments and how they may be integrated to stimulate new and innovative approaches for further lines of investigation and therapy.
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British Journal of Haematology
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© 2023 The Authors. British Journal of Haematology published by British Society for Haematology and John Wiley & Sons Ltd.
This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
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Cardiovascular medicine and haematology
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Bednarska, K; Chowdhury, R; Tobin, JWD; Swain, F; Keane, C; Boyle, S; Khanna, R; Gandhi, MK, Epstein–Barr virus-associated lymphomas decoded, British Journal of Haematology, 2023