Binucleated Myocytes and Heart Weight: A Preliminary Study Linking Cardiac Hypertrophy and Myocyte Hypertrophy
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Garland, Jack
Thompson, Melissa
Ondruschka, Benjamin
Da Broi, Ugo
Tse, Rexson
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Abstract
Hypertrophy of the heart is assessed by heart weight (and dimensions) and myocyte hypertrophy. Establishing an association between the two may be useful in assessing hypertrophy in cases where there are limitations in assessing the heart weight. This preliminary study explored the association between the number of binucleated myocytes (a feature of myocyte hypertrophy) in a randomly chosen single high-power field of the left ventricular free wall and heart weight in an adult White population. It also compared the number of binucleated myocytes between cases with increased heart weight (>400 g in female and >500 g in male) and cases with normal heart weight. Heart weight and number of binucleated myocytes correlated significantly in male only. Increased heart weight had a significantly higher number of binucleated myocytes, with 8.5 binucleated myocytes being able to segregate cases with increased heart weight (74% sensitivity and 79% specificity). The results of this study showed the number of binucleated myocytes may have a complementary role in assessing hypertrophy of the heart.
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The American Journal of Forensic Medicine and Pathology
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This is a non-final version of an article published in final form in The American Journal of Forensic Medicine and Pathology ():10.1097/PAF.0000000000000869, July 31, 2023.
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Gadsby, Z; Garland, J; Thompson, M; Ondruschka, B; Da Broi, U; Tse, R, Binucleated Myocytes and Heart Weight: A Preliminary Study Linking Cardiac Hypertrophy and Myocyte Hypertrophy, The American Journal of Forensic Medicine and Pathology, 2023