Synthetic vaccines targeting Mincle through conjugation of trehalose dibehenate
File version
Author(s)
Maxwell, Joshua WC
Ismanto, Hendra S
Ashhurst, Anneliese S
Artner, Lukas M
Rudrawar, Santosh
Britton, Warwick J
Yamasaki, Sho
Payne, Richard J
Griffith University Author(s)
Primary Supervisor
Other Supervisors
Editor(s)
Date
Size
File type(s)
Location
License
Abstract
The covalent fusion of immunostimulatory adjuvants to immunogenic antigens is a promising strategy for the development of effective synthetic vaccines for infectious diseases. Herein, we describe the conjugation of a mycobacterial peptide antigen from the 6 kDa early secretory antigenic target (ESAT6) to a suitably functionalised trehalose dibehenate (TDB), a potent glycolipid adjuvant targeting macrophage inducible C-type lectin (Mincle).
Journal Title
Chemical Communications
Conference Title
Book Title
Edition
Volume
58
Issue
49
Thesis Type
Degree Program
School
Publisher link
Patent number
Funder(s)
Grant identifier(s)
Rights Statement
Rights Statement
Item Access Status
Note
Access the data
Related item(s)
Subject
Science & Technology
Physical Sciences
Chemistry, Multidisciplinary
Chemistry
PATTERN-RECOGNITION RECEPTORS
Persistent link to this record
Citation
Hanna, CC; Maxwell, JWC; Ismanto, HS; Ashhurst, AS; Artner, LM; Rudrawar, S; Britton, WJ; Yamasaki, S; Payne, RJ, Synthetic vaccines targeting Mincle through conjugation of trehalose dibehenate, Chemical Communications, 2022, 58 (49), pp. 6890-6893