The diverse class of antimicrobial proteins/peptides known as bacterio-cins from lactic acid bacteria (LAB) has the potential to be employed as bio-preservatives. They exhibit a variety of antibacterial actions across the antibacterial spectrum at low doses, in addition to heat and pH constancy in food. Eminent bacteriocin synthesis is expected in a complicated medium. Yet, the such broth is too costly for a profitable manufacturing technique. It is necessary to employ food-grade media to create stable temperature, broad-division bacteriocins with utmost particular action before using them as food bio-preservatives. Bacteriocins’ under cede in the food-grade environment and labor-intensive, overpriced detoxifi-cation techniques, which are appropriate at the laboratory size but not at the industrial level, are the main obstacles to their use as food bio-preservatives. The current review focuses on the manufacture of bacteriocins utilizing complicated and food-grade medium and principally examines the bacteriocin manufacture variants, broth utilized, various manufacture techniques used, and the impact of varied generation methods on bacteriocin production. The purifying techniques developed for efficient bacteriocin recovery at both small and large scales are also a focus of this investigation.