In Vivo Efficacy of a Chimeric Peptide Derived from the Conserved Region of the M Protein against Group C and G Streptococci
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Malcolm, Jessica
Magor, Graham
Good, Michael F
Batzloff, Michael R
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Abstract
The J8 peptide from the conserved region of the M protein protects against group A streptococcus infections. In this study, we demonstrate that vaccination with a J8-containing formulation induces IgG that recognizes and binds group C and G streptococci. Moreover, this formulation has the potential to provide protection against infections caused by these organisms.
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Clinical and Vaccine Immunology
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19
Issue
12
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© 2012 American Society for Microbiology. The attached file is reproduced here in accordance with the copyright policy of the publisher. Please refer to the journal's website for access to the definitive, published version.
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Subject
Bacteriology
Infectious agents
Immunology