The Brisbane River serves multiple functions in both its upper catchment and its lower reaches. The lower reaches are highly urbanized where the river flows through Australia's third largest city, and here the river sustains transport activities, waste water disposal, a port, and both motorized recreation and active and passive non-motorized recreation. In the city the river also serves as a locality for community events, as a cultural icon and as a residential neighbour. Many of these functions are spatially and temporally congruent and, amongst other issues, this congruency has the potential to generate significant levels of noise conflict. This paper describes the approach adopted to assess the nature and extent of noise conflicts and to develop a comprehensive strategy of noise management - all as part of a larger scheme for an integrated approach to manage the Brisbane River and its catchment. Noise management strategies recommended for implementation include noise zoning of the river, planning and approval processes for land-based waterway facilities, noise planning and approval processes for residential and other noise-sensitive uses, codes of practice for rowing and similar activities, as well as the more conventional approach of regulatory limits on river-based noise sources. The paper demonstrates that a wide range of strategies are necessary to handle complex pollution problems of this sort, and provides a model of comprehensive action for management of noise from river-related activities that may find application elsewhere.