Austrocolorone B and austrocolorin B1, cytotoxic anthracenone dimers from the Tasmanian mushroom Cortinarius vinosipes Gasparini
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Thompson, Dion R
Tiralongo, Evelin
Ratkowsky, David
May, Tom W
Gill, Melvyn
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Abstract
The yellow dihydroanthracenone dimer, austrocolorin B1 and the unique violet-red 1,4-anthraquinone dimer, austrocolorone B, were isolated from the Tasmanian mushroom Cortinarius vinosipes and their structures and stereochemistry were determined from spectroscopic data. Austrocolorin B1 and austrocolorone B were found to exhibit potent cytotoxic activity in vitro against the murine lymphoblast (P388D1) cell line with IC50 values in the range 10-31 ug/mL.
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Tetrahedron Letters
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52
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42
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© 2011 Elsevier. This is the author-manuscript version of this paper. Reproduced in accordance with the copyright policy of the publisher. Please refer to the journal's website for access to the definitive, published version.
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Medicinal and biomolecular chemistry
Organic chemistry
Natural products and bioactive compounds
Biochemistry and cell biology