Transmembrane Protein 39A Promotes the Replication of Encephalomyocarditis Virus via Autophagy Pathway
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Ma, Ruixian
Li, Qian
Li, Shengjun
Zhang, Haixia
Xie, Jingying
Bai, Jialin
Idris, Adi
Feng, Ruofei
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Abstract
Encephalomyocarditis virus (EMCV) causes encephalitis, myocarditis, neuropathy, reproductive disorders, and diabetes in animals. EMCV is known to induce cell autophagy; however, the molecular mechanisms underlying this remain unclear. Here, we show that the type III-transmembrane protein, transmembrane protein 39A (TMEM39A), plays a critical role in EMCV replication. We showed that EMCV GS01 strain infection upregulated TMEM39A expression. Importantly, EMCV induced autophagy in a range of host cells. The autophagy chemical inhibitor, 3-MA, inhibited EMCV replication and reduced TMEM39A expression. This is the first study demonstrating TMEM39A promoting the replication of EMCV via autophagy. Overall, we show that TMEM39A plays a positive regulatory role in EMCV proliferation and that TMEM39A expression is dependent on the autophagy pathway.
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Frontiers in Microbiology
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10
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© 2019 Li, Ma, Li, Li, Zhang, Xie, Bai, Idris and Feng. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
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Medical microbiology
Soil sciences
Microbiology
Science & Technology
Life Sciences & Biomedicine
transmembrane protein 39A
encephalomyocarditis virus
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Li, X; Ma, R; Li, Q; Li, S; Zhang, H; Xie, J; Bai, J; Idris, A; Feng, R, Transmembrane Protein 39A Promotes the Replication of Encephalomyocarditis Virus via Autophagy Pathway, Frontiers in Microbiology, 2019, 10