Hypertension, Left Ventricular Hypertrophy, and Myocardial Ischemia
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Dunn, FG
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Abstract
The risks associated with hypertension emerge through a series of complex interactions. Myocardial ischemia is the major contributor to this risk. The mechanisms driving ischemia reflect many of the key factors in hypertension, including endothelial and neurohumoral factors, fibrosis, and hemodynamics. Left ventricular hypertrophy and fibrosis are of fundamental importance and together with hemodynamics provide an optimal template for myocardial ischemia. Understanding the pathophysiology has aided a more rational management approach but challenges remain which, if surmounted, will have an impact on the morbidity and mortality caused by myocardial ischemia in patients with hypertension.
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Medical Clinics of North America
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101
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1
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Subject
Clinical sciences
Hypertension
Ischemia
Management
Mechanisms
Perfusion
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Citation
Stanton, T; Dunn, FG, Hypertension, Left Ventricular Hypertrophy, and Myocardial Ischemia, Medical Clinics of North America, 2017, 101 (1), pp. 29-41