The purpose of this study is to evaluate the therapeutic effects of MLS laser on clinical outcomes of flapless dental implants placed using split mouth study and to measure patients’ satisfaction using visual analogue scale in in post menopause women age 50 years or over. Materials and methods: This study is a retrospective split mouth study on the therapeutic effects of MLS laser on the outcomes of flapless involving the study of dental records of 26 post-menopause of patients undergoing bilateral implant surgery in the posterior maxilla. A total of 65 implants with no augmentative procedures were selected from 26 patients for the study. Flapless implant technique was used for both sides of the jaw. The patients were divided into two groups: the control group had 32 implants and had sham MLS laser treatment, and the test group consisted of 33 implants treated with MLS Mphi laser at day one, day 7 and day 28. Only those patients with complete dental record were involved in this study. The treatment results were calculated via key words: Satisfaction, Implant Survival, Visual Analogue Scale (VAS), Periotest, X-ray assessment. Results and discussion: The findings illustrated that therapeutic MLS Laser treatment had a slightly better outcomes as contrast to the control side: survival rate (100.0% and 96.9%), Utilizing VAS (0–10), MLS Laser treatment in test group had less: pain, swelling but no difference in bleeding and speech impairment and had better overall satisfaction at one day and one week than the control side (*P < 0.05). No significant discrepancy in bone resorption at 3 months. After 6 months, bone change in the control group vs the test group was statistically significant [−0.56 (±0.52) vs. +0.12 (±0.50), **P < 0.05]. No statistical dissimilarity in Periotest Value (PTV). Conclusion: Therapeutic MLS Laser in implant flapless surgery is a an adjunctive minimal invasive, efficacious, and innovative method that can deliver a significantly superior early phase satisfaction, minimal bone loss, less pain, less complications, and similar PTV as contrast to the control side.