Early Motor Repertoire of Very Preterm Infants and Relationships with 2-Year Neurodevelopment

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Kwong, Amanda K-L
Boyd, Roslyn N
Chatfield, Mark D
Ware, Robert S
Colditz, Paul B
George, Joanne M
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2022
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Abstract

The Motor Optimality Score, revised (MOS-R) is an extension of the Prechtl General Movements Assessment. This study aims to determine the relationship between MOS-R and 2-year neurodevelopmental outcomes in a cohort of 169 infants born very preterm (<31 weeks’ gestational age), and to examine the predictive validity of the MOS-R at 3–4 months’ corrected age (CA) above perinatal variables associated with poor outcomes, including Prechtl fidgety movements. Development at 2 years’ CA was assessed using Bayley Scales of Infant and Toddler Development, Third edition (Bayley-III) (motor/cognitive impairment: Bayley-III ≤ 85) and Neurological, Sensory, Motor, Developmental Assessment (NSMDA) (neurosensory motor impairment: NSMDA ≥ 12). Cerebral palsy (CP) was classified at 2 years as definite or clinical. The MOS-R was related to 2-year outcomes: Bayley-III motor (BMOS-R = 1.24 95% confidence interval (0.78, 1.70)), cognitive (BMOS-R = 0.91 (0.48, 1.35)), NSMDA scores (BMOS-R = −0.34 (−0.42, −0.25)), definite CP (odds ratio [OR] 0.67 (0.53, 0.86)), clinical CP (OR 0.74 (0.66, 0.83)) for each 1-point increase in MOS-R. MOS-R ≤ 23 predicted motor (sensitivity 78% (60–91%); specificity 63% (54–72%)) and neurosensory motor impairment (sensitivity 86% (64–97%); specificity 59% (51–68%)). The MOS-R is strongly related to CP and motor and cognitive delay at 2 years and is a good predictor of motor and neurosensory motor impairment.

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Journal of Clinical Medicine

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11

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7

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© 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Science & Technology

Life Sciences & Biomedicine

Medicine, General & Internal

General & Internal Medicine

preterm infant

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Kwong, AK-L; Boyd, RN; Chatfield, MD; Ware, RS; Colditz, PB; George, JM, Early Motor Repertoire of Very Preterm Infants and Relationships with 2-Year Neurodevelopment, Journal of Clinical Medicine, 2022, 11 (7), pp. 1833

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