Core–shell noble-metal@zeolitic-imidazolate-framework nanocarriers with high cancer treatment efficiency in vitro
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Pang, Kanglei
Liu, Wenwen
Tian, Yue
Chang, Lin
Liu, Xu
Zhao, Meiting
Liu, Yong
Li, Yantao
Jiang, Xingyu
Song, Rui
Liu, Yaling
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Abstract
Core–shell Au@zeolitic-imidazolate-framework-8 (ZIF-8) nanostructures are reported as a nanocarrier with both a high drug payload and high cancer treatment efficiency in vitro. Impressively, when used as multifunctional drug delivery vehicles, such core–shell Au@ZIF-8 nanostructures not only exhibit light- and pH-controlled drug release properties, but also provide two synergetic therapeutic modes for cancer treatment, resulting in 98% cell-killing activity after 30 min light irradiation followed by 24 h incubation even though HeLa cells are treated only by Au@ZIF-8 nanostructures loaded with 10 μM doxorubicin hydrochloride. All these results demonstrate the promising applications of this type of core–shell nanostructure in biomedical fields.
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Journal of Materials Chemistry B
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7
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7
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Macromolecular and materials chemistry
Biomedical engineering