Flexible electronic devices are widely used in daily life. Among them, flexible sensors are widely studied by their potential for extensive applications. Materials are one of the essential foundations for making electronic devices. Due to the excellent unique properties of organic and inorganic hybrid materials, they are widely used in the manufacture of flexible sensors. Flexible sensor technology is developed by combining organic and inorganic materials and these hybrid materials can ensure the high frequency and high‐speed conductive property of a device while making the device flexible. In this review, the main three elements of sensors are mentioned and the materials selections in different elements are reviewed. After investigating the materials’ performance requirements of sensors, the performance of hybrid materials in sensors is comprehensively summarized according to the type of the sensor. Finally, some challenges and future directions of development are summarized and presented for flexible sensors based on such promising materials.