The investigation of the wave-induced soil response is extremely significant for sake of submarine pipelines. Unlike conventional approaches, in this paper, a meshfree model for the wave-seabed interactions around an offshore pipeline is established. The pipeline is considered to be fully buried or partially buried in a trench layer surrounding impermeable walls. The proposed model is validated with the analytical solution, laboratory experiments and numerical models available in the literature. Then, a parametric study is carried out to examine the effects of configuration of a pipeline on the wave-induced soil response in the vicinity of a pipeline.