Management of patients with hepatocellular adenoma: a single-institution experience

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Nahm, Christopher B
Parker, Nicholas
Gundara, Justin S
Gill, Anthony J
Bhimani, Nazim
Samra, Jaswinder S
Hugh, Thomas J
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2020
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Abstract

Background: Hepatocellular adenoma (HCA) is a rare benign liver tumour that may cause diagnostic and management dilemmas. This study describes the clinical and histopathological characteristics of patients who were treated for HCA in a tertiary referral hospital over a 17-year period. Methods: A retrospective review was performed of prospectively collected data of all patients treated for HCA within the Northern Upper GI Surgical unit between 2002 and 2018. Immunohistochemical β-catenin expression was evaluated. Results: Thirty-two patients had histological or radiologically confirmed HCA. Twenty-eight patients underwent 30 operations and four patients were treated conservatively. The median age of the operative group was 43 years (range 19–83) and most patients were female (95%). The median body mass index was 28.7 (range 20–51), and nine patients (33%) were obese. Seven patients (25%) had multifocal HCA. Evidence of prior bleed or rupture or a perceived risk of either a bleed or malignant change (i.e. tumours ≥50 mm) were the most common indications for resection. There were no perioperative mortalities. Nuclear expression of β-catenin by immunohistochemical staining was negative in all cases and there was no malignancy identified in any of the resected lesions. Two patients required transarterial embolization and two patients required a second liver resection for residual HCA. Conclusion: HCA is a rare lesion predominantly affecting females. Haemorrhage is seen frequently on imaging studies, occasionally requiring urgent angioembolization and/or surgical intervention. Malignant transformation and immunohistochemical β-catenin expression are uncommon. HCA may be multifocal and residual tumours usually require ongoing surveillance and occasionally further intervention.

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ANZ Journal of Surgery

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Clinical sciences

Science & Technology

Life Sciences & Biomedicine

Surgery

hepatocellular adenoma

retrospective review

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Nahm, CB; Parker, N; Gundara, JS; Gill, AJ; Bhimani, N; Samra, JS; Hugh, TJ, Management of patients with hepatocellular adenoma: a single-institution experience, ANZ Journal of Surgery, 2020

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