Association of -592 Region of IL-10 Polymorphisms with Asthma in South-Eastern Iranian Patients

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Author(s)
Hakimizadeh, Elham
Arababadi, Mohammad Kazemi
Hassanshahi, Gholamhossein
Ahmadabadi, Behzad Nasiri
Hakimi, Hamid
Rezaeian, Mohsen
Salehabadi, Vajihe Akbarpour
Yousefidaredor, Hassan
Abousaidi, Hamid
Kennedy, Derek
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2012
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Abstract

Background: Cytokines are considered important factors for the pathogenesis of asthma as they play a key role in the regulation of immune responses. The aim of this study was to investigate the association between this disease and polymorphisms in the -592 region of the IL-10 gene. METHODS: This study was carried out on 100 asthmatic patients and 100 healthy controls. PCR-RFLP was applied to examine the polymorphisms in the -592 region of the IL-10 gene. RESULTS: Our results showed a significant difference between patients and controls in terms of genotypes and alleles of the -592 region of the IL-10 gene. CONCLUSIONS: According to our results, it can be concluded that the IL-10 promoter polymorphisms may play a crucial role in the pathogenesis of asthma.

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Clinical Laboratory

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58

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3-Apr

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© 2012 Clinical Laboratory Publications. The attached file is reproduced here in accordance with the copyright policy of the publisher. Please refer to the journal's website for access to the definitive, published version.

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Clinical sciences

Medical genetics (excl. cancer genetics)

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