Analysis of Electrode Configurations for Measuring Cardiac Tissue Conductivities and Fibre Rotation
File version
Author(s)
Johnston, Peter R
Kilpatrick, David
Griffith University Author(s)
Primary Supervisor
Other Supervisors
Editor(s)
Date
Size
149779 bytes
File type(s)
application/pdf
Location
License
Abstract
This paper describes a multi-electrode grid, which could be used to determine cardiac tissue parameters by direct measurement. A two pass process is used, where potential measurements are made, during the plateau phase of the action potential, on a subset of these electrodes and these measurements are used to determine the bidomain conductivities. In the first pass, the potential measurements are made on a set of 'closely-spaced' electrodes and the parameters are fitted to the potential measurements in an iterative process using a bidomain model and a solver based on a modified Shor's r-algorithm. This first pass yields the extracellular conductivities. The second pass is similar except that a 'widely-spaced' electrode set is used and this time the intracellular conductivities are recovered. In addition, it is possible to determine the fibre rotation throughout the tissue, since the bidomain model used here is able to include the effects of fibre rotation. In the simulation studies presented here, the model is solved with known conductivities, on each of the two subsets of electrodes, to generate two sets of 'measured potentials.' Conductivities are then recovered by solving an inverse problem based on the measured potentials, to which various levels of noise are added. For example, simulations in the first pass are performed using an electrode spacing of 500 孬 for a situation where the longitudinal and transverse space constants are 769 and 308 孬 respectively. These give very accurate average percentage relative errors for the longitudinal and transverse extracellular conductivities, over five simulations with 1% noise added, of 0.3 and 0.2%. Twenty-five second pass simulations, on a 1 mm grid, yield average percentage relative errors of 3.8, 2.6 and 1.4% for the corresponding intracellular values and the fibre rotation angle, respectively.
Journal Title
Annals of Biomedical Engineering
Conference Title
Book Title
Edition
Volume
34
Issue
6
Thesis Type
Degree Program
School
Publisher link
Patent number
Funder(s)
Grant identifier(s)
Rights Statement
Rights Statement
© 2006 Springer-Verlag. This is the author-manuscript version of this paper. Reproduced in accordance with the copyright policy of the publisher. The original publication is available at www.springerlink.com
Item Access Status
Note
Access the data
Related item(s)
Subject
Engineering
Biomedical and clinical sciences