An Occult HPV-Driven Oropharyngeal Squamous Cell Carcinoma Discovered Through a Saliva Test
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Vasani, Sarju
Taheri, Touraj
Walsh, Laurence J
Hughes, Brett GM
Kenny, Lizbeth
Punyadeera, Chamindie
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Abstract
Oropharyngeal cancer (OPC) caused by human papillomavirus (HPV) is a rising global concern. Early lesions are small and are often located in difficult to access areas (such as the crypts of the tonsils or base of tongue). Unlike cervical cancer, there is no standard or routine screening program for HPV-driven OPC. HPV DNA from OPC tumors may shed directly into saliva, and this can be used as a biomarker for early diagnosis. In this study, we report the first-ever clinically occult OPC in an asymptomatic patient discovered through a saliva test. This case relied upon serial measurements of HPV-16 DNA in saliva, which fell to undetectable levels following low morbidity, curative treatment.
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Frontiers in Oncology
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10
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© 2020 Tang, Vasani, Taheri, Walsh, Hughes, Kenny and Punyadeera. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
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Oncology and carcinogenesis
Science & Technology
Life Sciences & Biomedicine
Oncology
human papillomavirus
oropharyngeal cancer
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Tang, KD; Vasani, S; Taheri, T; Walsh, LJ; Hughes, BGM; Kenny, L; Punyadeera, C, An Occult HPV-Driven Oropharyngeal Squamous Cell Carcinoma Discovered Through a Saliva Test, Frontiers in Oncology, 2020, 10, pp. 00408