New tetracyclic 1,4-oxazepines constructed via practically simple tandem condensation strategy from readily available synthons
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Author(s)
V. Sapegin, Alexander
A. Kalinin, Stanislav
V. Smirnov, Alexey
V. Dorogov, Mikhail
Krasavin, Mikhail
A. Kalinin, Stanislav
V. Smirnov, Alexey
V. Dorogov, Mikhail
Krasavin, Mikhail
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Date
2014
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Abstract
A streamlined synthetic methodology towards novel tetracyclic 1,4-oxazepines from readily available precursors is described. The compounds, designed as more soluble version of the earlier described, poorly soluble dibenzo[b,f][1,4]oxazepines, were obtained in high yields and as a single regioisomer as a result of three tandem chemical events-nucleophilic aromatic substitution, Smiles rearrangement and denitrocyclization.
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Tetrahedron
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70
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5
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Medicinal and Biomolecular Chemistry not elsewhere classified
Medicinal and Biomolecular Chemistry
Organic Chemistry