Bioactive Materials Facilitating Targeted Local Modulation of Inflammation

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Tan, Richard P
Chan, Alex HP
Wei, Simon
Santos, Miguel
Lee, Bob SL
Filipe, Elysse C
Akhavan, Behnam
Bilek, Marcela M
Ng, Martin KC
Xiao, Yin
Wise, Steven G
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2019
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Abstract

Cardiovascular disease is an inflammatory disorder that may benefit from appropriate modulation of inflammation. Systemic treatments lower cardiac events but have serious adverse effects. Localized modulation of inflammation in current standard treatments such as bypass grafting may more effectively treat CAD. The present study investigated a bioactive vascular graft coated with the macrophage polarizing cytokine interleukin-4. These grafts repolarize macrophages to anti-inflammatory phenotypes, leading to modulation of the pro-inflammatory microenvironment and ultimately to a reduction of foreign body encapsulation and inhibition of neointimal hyperplasia development. These resulting functional improvements have significant implications for the next generation of synthetic vascular grafts.

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JACC: Basic to Translational Science

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4

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1

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© 2019 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International (CC BY-NC-ND 4.0) License, which permits unrestricted, non-commercial use, distribution and reproduction in any medium, providing that the work is properly cited.

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Cardiovascular medicine and haematology

Clinical sciences

Science & Technology

Life Sciences & Biomedicine

Cardiac & Cardiovascular Systems

Cardiovascular System & Cardiology

covalent biomolecule immobilization

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Tan, RP; Chan, AHP; Wei, S; Santos, M; Lee, BSL; Filipe, EC; Akhavan, B; Bilek, MM; Ng, MKC; Xiao, Y; Wise, SG, Bioactive Materials Facilitating Targeted Local Modulation of Inflammation, JACC: Basic to Translational Science, 2019, 4 (1), pp. 56-71

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