The study presents the design and fabrication process of a novel microfluidic active droplet generator and development of a controller to actuate the integrated micropumps. The proposed active droplet generator consists of a droplet generation geometry and two microfluidic pumps to control the flow rate of the continuous phase fluid and the dispersed phase fluid to generate a microflow towards the droplet generation geometry. The droplet generator is developed based on flow-focusing geometry. Proposed micropumps have a pump chamber and a reservoir. A layer by layer method is adapted in fabricating the active droplet generator in which Polymethyl Methacrylate (PMMA) is used as the material. A heat treating based bonding method is discussed in combining fabricated PMMA layers together. Piezoelectric transducer, which is used as the actuator, is made of Lead Zirconate Titanate (PZT) and integrated into the micropump geometry to produce the microflow. The developed controller is capable of providing a range of shapes, frequencies, and amplitudes for the input signal leading to successful operations of the active droplet generator.