Potential drawbacks to the use of Ultra Clean Ventilation (UCV) technology in modern operating theatres include difficulties with locating pendant lighting, excessive noise levels and excessive operational costs. The main benefits of using UCV technology however, is a reduction in postoperative Surgical Site Infection (SSI) rates. To solve the above challenge a novel surgical theatre centre has been designed to accommodate three state-of-the-art theatre suites, a seven-bed recovery ward, a fifteen-bed orthopaedic ward and attendant ancillary spaces. At the heart of the complex, the three unique theatre environments utilize innovative skirt-less ultra-clean laminar-flow ventilation canopies to help control airborne infection during surgical procedures. The novel approach allows uninterrupted use of multi-flexible lighting and surgical pendants, has been designed to minimise noise levels and utilises heat recovery to minimise running costs. The innovative approach to infection control is continued through into the detailed design of the theatre wall, ceiling and floor systems, and integrates with the overall strategy of creating a dramatic and stimulating working environment where traditionally aesthetic sterility was de rigueur.