Research on earthquake-induced collapse simulation has a great practical significance for supertall buildings. Although mega-braced frame-core tube buildings are one of the common high-rise structural systems in high seismic intensity regions, the failure mode and collapse mechanism of such a building under earthquake events are rarely studied. This paper thus aims to investigate the collapse behavior of a super-tall mega-braced frame-core tube building (H=550m) to be built in China in the high risk seismic zone with the maximum spectral acceleration of 0.9g (g represents the gravity acceleration). A finite element (FE) model of this building is constructed based on the fiber-beam and multi-layer shell models. The dynamic characteristics of the building are analyzed and the earthquake-induced collapse simulation is performed. Finally, the failure mode and mechanism of earthquake-induced collapse are discussed in some detail. This study will serve as a reference for the collapse-resistance design of super-tall buildings of similar type.