Motile Membrane Protrusions Regulate Cell-Cell Adhesion and Migration of Olfactory Ensheathing Glia

No Thumbnail Available
File version
Author(s)
Windus, Louisa CE
Claxton, Christina
Allen, Chelsea L
Key, Brian
St John, James A
Griffith University Author(s)
Primary Supervisor
Other Supervisors
Editor(s)

Bruce R Ransom, Helmut Hettenmann

Date
2007
Size
File type(s)
Location
License
Abstract

Olfactory ensheathing cells (OECs) are candidates for therapeutic approaches for neural regeneration due to their ability to assist axon regrowth in central nervous system lesion models. However, little is understood about the processes and mechanisms underlying migration of these cells. We report here that novel lamellipodial protrusions, termed lamellipodial waves, are integral to OEC migration. Time-lapse imaging of migrating OECs revealed that these highly dynamic waves progress along the shaft of the cells and are crucial for mediating cell-cell adhesion. Without these waves, cell-cell adhesion does not occur and migrational rates decline. The activity of waves is modulated by both glial cell line-derived neurotrophic factor and inhibitors of the JNK and SRC kinases. Furthermore, the activity of lamellipodial waves can be modulated by Mek1, independently of leading edge activity. The ability to selectively regulate cell migration via lamellipodial waves has implications for manipulating the migratory behavior of OECs during neural repair

Journal Title

Glia

Conference Title
Book Title
Edition
Volume

55

Issue

16

Thesis Type
Degree Program
School
Patent number
Funder(s)
Grant identifier(s)
Rights Statement
Rights Statement
Item Access Status
Note
Access the data
Related item(s)
Subject

Neurosciences

Persistent link to this record
Citation
Collections