Recently, wearable electronics for health monitoring have been demonstrated with considerable benefits for early-stage disease detection. This paper reports a flexible, bending-insensitive, bio-compatible and lightweight respiration sensor. The sensor consists of highly oriented carbon nanotube (HO-CNT) films embedded between electro-spun polyacrylonitrile (PAN) layers. By aligning carbon nanotubes between the PAN layers, the sensor exhibits a high sensitivity towards airflow (340 mV/(m/s)) and excellent flexibility and robustness. In addition, the HO-CNT sensor is insensitive to mechanical bending, making it suitable for wearable applications. We successfully demonstrated the attachment of the sensor to the human philtrum for real-time monitoring of the respiration quality. These results indicate the potential of HO-CNT flow sensor for ubiquitous personal health care applications.