Hesperine, a new imidazole alkaloid and α-synuclein binding activity of 1-methyl-1,2,7,8-tetrahydro-2,8-dioxoadenosine from the marine sponge Clathria (Thalysias) cf. hesperia
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Voser, TM
Er, S
Hlushchuk, I
Domanskyi, A
Airavaara, M
Ekins, MG
Mellick, GD
Carroll, AR
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Abstract
During a high-throughput screen of 300 Australian marine invertebrate extracts, the extract of the marine sponge Clathria (Thalysias) cf. hesperia was identified with α-synuclein binding activity. The bioassay-guided purification of this extract resulted in the isolation of 1-methyl-1,2,7,8-tetrahydro-2,8-dioxoadenosine (2) as the α-syn binder along with one new compound, hesperine (1), and five known compounds, indole-3-carboxaldehyde (3), (Z)-2′-demethylaplysinopsin (4), 2-amino-4′-hydroxyacetophenone (5), 4-hydroxybenzoic acid (6) and 4-hydroxybenzaldehyde (7). Herein, we report the structure elucidation of hesperine (1) and α-syn binding activity of 1-methyl-1,2,7,8-tetrahydro-2,8-dioxoadenosine (2)
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Results in Chemistry
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4
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© 2022 The Authors. Published by Elsevier B.V. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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Natural products and bioactive compounds
Medicinal and biomolecular chemistry
Marine and estuarine ecology (incl. marine ichthyology)
Neurosciences
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Prebble, DW; Voser, TM; Er, S; Hlushchuk, I; Domanskyi, A; Airavaara, M; Ekins, MG; Mellick, GD; Carroll, AR, Hesperine, a new imidazole alkaloid and α-synuclein binding activity of 1-methyl-1,2,7,8-tetrahydro-2,8-dioxoadenosine from the marine sponge Clathria (Thalysias) cf. hesperia, Results in Chemistry, 2022, 4, pp. 100302