The effect of preexisting medical comorbidities on the preeclamptic phenotype: a retrospective cohort study
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De Guingand, D
Reddy, M
Rowson, S
Rolnik, DL
Da Silva Costa, F
Davey, MA
Mol, BW
Wallace, EM
Palmer, KR
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Abstract
Objective:To compare the effect of comorbidities on the phenotype and outcomes of preeclampsia. Methods: A matched retrospective cohort study of women delivering at a tertiary maternity center following a diagnosis of preeclampsia. We collected data on signs and symptoms, biochemical markers, and maternal and perinatal outcomes. Results:We studied 474 women; 158 women with and 316 without comorbidities. Compared to women without comorbidities, women with comorbidities delivered earlier. They suffered fewer maternal but more neonatal complications. Conclusion: Women with comorbidities receive earlier intervention than women without comorbidities, which may lead to fewer maternal complications but worse neonatal outcomes.
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Hypertension in Pregnancy
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Paediatrics
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Tanner, MS; De Guingand, D; Reddy, M; Rowson, S; Rolnik, DL; Da Silva Costa, F; Davey, MA; Mol, BW; Wallace, EM; Palmer, KR, The effect of preexisting medical comorbidities on the preeclamptic phenotype: a retrospective cohort study, Hypertension in Pregnancy, 2021