Endodontic treatment in severely calcified canals is always a challenging task because it can result in accidents such as deviations or perforations. Recently, guided endodontics has become an alternative approach for pulp canal calcification, facilitating the location of root canals more predictably through the combined use of cone-beam computed tomography, oral scanning, and endodontic access guides. Although several reports have shown that guided endodontics is safer, faster, and can be performed without an operating microscope and by less experienced operators, the technique has limitations, and iatrogenesis may occur. This article describes the limitations of static-guided endodontics and possible causes of failures. In the present case, not fixing the guide to the bone and inaccuracies generated by manually performing mesh merger software led to root perforation. | Endodontic microsurgery was effective in resolving this case and should be considered the treatment of choice where guided endodontics cannot be employed safely or when it fails.