Protein crystal structures with ferrocene and ruthenocene-based enzyme inhibitors

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Salmon, Adam J
Williams, Michael L
Hofmann, Andreas
Poulsen, Sally-Ann
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2012
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Abstract

We have determined the protein X-ray crystal structures of four organometallic inhibitors in complex with their target enzyme carbonic anhydrase II. The barrel-shaped hydrophobic ferrocene and ruthenocene moieties have provided a structure-based avenue to better occupy the hydrophobic binding patch within the enzyme active site.

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Chemical Communications

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48

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17

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© 2012 Royal Society of Chemistry. This is the author-manuscript version of this paper. Reproduced in accordance with the copyright policy of the publisher. Please refer to the journal website for access to the definitive, published version.

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Chemical sciences

Biologically active molecules

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