Ameliorating effects of Raphanus sativus leaves on sodium arsenite-induced perturbation of blood indices in Swiss albino mice

Loading...
Thumbnail Image
File version
Author(s)
Dilruba, Sayada
Hasibuzzaman, MM
Rahman, Mashiur
Mohanto, Nayan Chandra
Aktar, Sharmin
Rahman, Atiqur
Hossain, Md Imam
Noman, Abu Shadat Mohammod
Nikkon, Farjana
Saud, Zahangir Alam
Hossain, Khaled
Griffith University Author(s)
Primary Supervisor
Other Supervisors
Editor(s)
Date
2017
Size
File type(s)
Location
Abstract

Objective: To evaluate the ameliorating effects of Raphanus sativus leaves (RSL) against sodium arsenite (Sa)-induced adverse effects through mice experiments. Methods:Swiss albino mice were divided into four equal groups: control, Sa, RSL, RSL + Sa. Sa (10 mg/kg body weight/day), and powder form of RSL (50 mg/kg body weight/day) were provided as food supplement orallty. Blood indices were measured using commercially available kits through colorimetric methods. Results: It was observed that lactate dehydrogenase, alkaline phosphatase, alanine aminotransferase, and aspartate aminotransferase activities were significantly (P < 0.05) higher in Sa-treated mice than those in the control group. RSL significantly reduced Sa-induced elevation of the activities of these enzymes in serum significantly (P < 0.05). Serum butyrylcholinesterase activity and high density lipoproteins cholesterol levels in Sa-treated mice were significantly (P < 0.05) lower than the control group, and the food supplementation of RSL could significantly (P < 0.05) prevent the reduction of Sa-mediated serum butyryl cholinesterase activity and high density lipoproteins cholesterol levels. RSL could also reduce the Sa-induced elevation of serum urea level significantly (P < 0.05). Conclusions: Results of this study suggest the protective or ameliorating effects of RSL on Sa-induced perturbation of blood indices are related to the hepatic, cardiovascular and kidney dysfunction. Therefore, RSL may be useful to reduce arsenic toxicity in human in the future.

Journal Title

Asian Pacific Journal of Tropical Biomedicine

Conference Title
Book Title
Edition
Volume

7

Issue

10

Thesis Type
Degree Program
School
Publisher link
Patent number
Funder(s)
Grant identifier(s)
Rights Statement
Rights Statement

© 2017 Hainan Medical University. Production and hosting by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http:// creativecommons.org/licenses/by-nc-nd/4.0/).

Item Access Status
Note
Access the data
Related item(s)
Subject

Biomedical and clinical sciences

Science & Technology

Life Sciences & Biomedicine

Tropical Medicine

Persistent link to this record
Citation

Dilruba, S; Hasibuzzaman, MM; Rahman, M; Mohanto, NC; Aktar, S; Rahman, A; Hossain, MI; Noman, ASM; Nikkon, F; Saud, ZA; Hossain, K, Ameliorating effects of Raphanus sativus leaves on sodium arsenite-induced perturbation of blood indices in Swiss albino mice, Asian Pacific Journal of Tropical Biomedicine, 2017, 7 (10), pp. 915-920

Collections