Ameliorating effects of Raphanus sativus leaves on sodium arsenite-induced perturbation of blood indices in Swiss albino mice

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Dilruba, Sayada
Hasibuzzaman, MM
Rahman, Mashiur
Mohanto, Nayan Chandra
Aktar, Sharmin
Rahman, Atiqur
Hossain, Md Imam
Noman, Abu Shadat Mohammod
Nikkon, Farjana
Saud, Zahangir Alam
Hossain, Khaled
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2017
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http://creativecommons.org/licenses/by-nc-nd/4.0/
Abstract

Objective: To evaluate the ameliorating effects of Raphanus sativus leaves (RSL) against sodium arsenite (Sa)-induced adverse effects through mice experiments. Methods:Swiss albino mice were divided into four equal groups: control, Sa, RSL, RSL + Sa. Sa (10 mg/kg body weight/day), and powder form of RSL (50 mg/kg body weight/day) were provided as food supplement orallty. Blood indices were measured using commercially available kits through colorimetric methods. Results: It was observed that lactate dehydrogenase, alkaline phosphatase, alanine aminotransferase, and aspartate aminotransferase activities were significantly (P < 0.05) higher in Sa-treated mice than those in the control group. RSL significantly reduced Sa-induced elevation of the activities of these enzymes in serum significantly (P < 0.05). Serum butyrylcholinesterase activity and high density lipoproteins cholesterol levels in Sa-treated mice were significantly (P < 0.05) lower than the control group, and the food supplementation of RSL could significantly (P < 0.05) prevent the reduction of Sa-mediated serum butyryl cholinesterase activity and high density lipoproteins cholesterol levels. RSL could also reduce the Sa-induced elevation of serum urea level significantly (P < 0.05). Conclusions: Results of this study suggest the protective or ameliorating effects of RSL on Sa-induced perturbation of blood indices are related to the hepatic, cardiovascular and kidney dysfunction. Therefore, RSL may be useful to reduce arsenic toxicity in human in the future.

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Asian Pacific Journal of Tropical Biomedicine
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7
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10
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© 2017 Hainan Medical University. Production and hosting by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http:// creativecommons.org/licenses/by-nc-nd/4.0/).
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Biomedical and clinical sciences
Science & Technology
Life Sciences & Biomedicine
Tropical Medicine
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Dilruba, S; Hasibuzzaman, MM; Rahman, M; Mohanto, NC; Aktar, S; Rahman, A; Hossain, MI; Noman, ASM; Nikkon, F; Saud, ZA; Hossain, K, Ameliorating effects of Raphanus sativus leaves on sodium arsenite-induced perturbation of blood indices in Swiss albino mice, Asian Pacific Journal of Tropical Biomedicine, 2017, 7 (10), pp. 915-920
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